A new study led by Gian Marco Ludovici, Paola Amelia Tassi, Alba Iannotti, Colomba Russo, Riccardo Quaranta, Guglielmo Manenti, and Andrea Malizia sheds light on a potentially high-impact zoonotic virus, HKU5-CoV-2. This novel lineage within the Merbecovirus subgenus—originating from bats—is phylogenetically related to the Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Significantly, HKU5-CoV-2 has demonstrated the ability to bind to the human angiotensin-converting enzyme 2 (ACE2) receptor, the same entry pathway used by SARS-CoV-2, enabling potential infection of human cells. While no human cases have been reported to date, the virus’s zoonotic potential raises concerns over possible spillover events that could lead to widespread transmission and, under certain conditions, pandemics.
The paper analyses the virus’s virological features, epidemiological risks, and clinical implications, stressing its capacity to cross species barriers and cause severe respiratory illness. To proactively address such a threat, the authors propose a CBRNE-based pandemic prevention framework—an approach traditionally reserved for high-consequence biological threats. This framework emphasizes:
• Early detection via advanced genomic surveillance.
• Rapid containment to limit spread.
• Targeted medical countermeasures development.
• Clear risk communication to the public.
• International collaboration for coordinated action.
By integrating lessons from previous coronavirus outbreaks, the proposed strategy aims to mitigate the consequences of a potential HKU5-CoV-2 spillover and ensure a coordinated, efficient global response.
This research underscores the urgent need for preparedness in the face of emerging zoonotic viruses and offers a concrete roadmap for managing future biological threats with pandemic potential.
FULL CITATION:
Ludovici, Gian Marco; Tassi, Paola Amelia; Iannotti, Alba; Russo, Colomba; Quaranta, Riccardo; Manenti, Guglielmo; Malizia, Andrea. (2025) Emerging zoonotic threats: HKU5-CoV-2 and the CBRNE approach to pandemic prevention. Infectious Diseases & Immunity ():10.1097/ID9.0000000000000171, August 14, 2025. | DOI: 10.1097/ID9.0000000000000171
link: https://journals.lww.com/idi/fulltext/9900/emerging_zoonotic_threats__hku5_cov_2_and_the.116.aspx
Write a comment