We are pleased to announce the publication of a new open access review article in Journal of Global Biosecurity:
“Nipah Virus Outbreaks: A CBRNE Framework for Global Biocontainment”
Authors: Gian Marco Ludovici, Paola Amelia Tassi, Alba Iannotti, Colomba Russo, Riccardo Quaranta, Gabriele Giuga, Sabrina Rao & Andrea Malizia (2025)
👉 https://jglobalbiosecurity.com/index.php/up-j-gb/article/view/327
Abstract
Nipah virus (NiV), a deadly zoonotic pathogen with a fatality rate ranging from 40–75%, continues to pose a major pandemic threat, as recently demonstrated by outbreaks in Kerala, India (2023 and 2024). These events underline NiV’s potential for human-to-human transmission, particularly in healthcare settings, and its capacity to cause severe respiratory and neurological disease. In the absence of approved vaccines or therapeutics, the review explores the integration of CBRNE (Chemical, Biological, Radiological, Nuclear, and Explosive) strategies to enhance outbreak containment through military-developed protocols.
The proposed framework includes:
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High-level biocontainment units and mobile isolation pods for rapid response,
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Aerosolized disinfectant systems and controlled movement zones,
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Strict corpse management procedures,
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Advanced protection measures for healthcare workers,
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Broader preparedness through preventive training, interagency coordination, and strategic resource allocation.
By adapting CBRNE methodologies, the review demonstrates how military-civilian integrated responses can significantly reduce transmission risks while preserving essential social functions. The lessons drawn from recent epidemic responses in India show the potential of CBRNE approaches in mitigating emerging global biological threats.
Significance
This publication provides policymakers and practitioners with actionable recommendations for addressing Nipah virus outbreaks within a unified biocontainment architecture, highlighting how multidisciplinary preparedness can strengthen resilience against high-risk biological threats.
Special recognition goes to Dr. Gian Marco Ludovici, Principal Investigator (P.I.), for leading this important work with vision and commitment, and to all co-authors — Paola Amelia Tassi, Alba Iannotti, Colomba Russo, Riccardo Quaranta, Gabriele Giuga, Sabrina Rao & Andrea Malizia — for their valuable contributions.
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